• The Future of Fertility has Arrived.

  • The Future of Fertility is Simplicity.

About Us

DxNow is combining novel, portable bio-imaging systems with microfluidic-based consumables for life science applications leveraging exclusively licensed technologies developed in the Demirci Bio-Acoustic MEMS in Medicine Labs (BAMM Labs) at Harvard Medical School/Brigham & Women’s Hospital and Stanford Medicine.

Our initial products address significant market needs in fertility clinics and forensics labs. We are in the process of establishing and expanding our commercialization efforts worldwide through key geographically-specific distribution partners.

Founded in 2013, DxNow is a privately-held Delaware C corporation whose corporate headquarters and primary research and development labs are located in Montgomery County, Maryland. This location offers close proximity to Washington, DC, the USFDA, USPTO, NIH, CMS and other agencies relevant to DxNow’s business interests, as well three major airports.

Our mission is to develop and commercialize novel tools that:
  • Deliver improvements in assisted reproductive technology (ART) in humans and animals
  • Facilitate faster identification of individuals for prosecution within the criminal justice system
  • Enable advances in life science research and applied markets
  • Provide faster, more cost-effective diagnostic solutions for chronically ill patients and their caregivers
  • Technology

    Our novel bio-imaging and microfluidic-based consumable platform technologies position DxNow to:

    • Address multiple parallel markets
    • Enable detection and quantification across a broad multi-scale spectrum and addresses multiple bio targets
    • Eliminate sample preparation steps, facilitating work with unprocessed whole blood, saliva, semen, serum, urine and in vitro cultures on chips, in dishes or plates

  • Intellectual Property

    DxNow’s products are based on exclusively licensed worldwide patent rights to platform technologies developed by Dr. Demirci and his team at the Demirci Bio-Acoustic MEMS in Medicine Labs (BAMM) at Brigham & Women’s Hospital and Stanford Medicine. The patents pertain to:

    • Invention for the analysis and sorting of motile cells, as described and claimed in PCT/US2012/038680 and an invention for the sorting of large volumes of sperm cells as described and claimed in U.S. Patent Application US61/906,740 and International Application WO2015077333 (A1).
    • Inventions pertaining to shadow imaging for detection and characterization of cells (US 61/704,692, PCT/US13/61292, and US 62/121,603)
    • Additionally, DxNow filed PCT/US 2015/053370 in September 2015 for applications in forensics under license from and jointly-owned with Stanford and the Brigham & Women’s Hospital.

  • The Demirci BAMM Labs

    The Demirci Bio-Acoustic MEMS in Medicine Labs (BAMM) specialize in applying micro- and nanoscale technologies to problems in medicine at the interface between micro/nanoscale engineering and medicine—applying innovative technologies to clinical problems. In this interdisciplinary space at the convergence of engineering, biology and materials science, the goal of the BAMM Labs is to create novel technologies for disposable point-of-care (POC) diagnostics and monitoring of diseases. Applications are unified around expertise in cell manipulation in nanoliter volumes by establishing microfluidic platforms to provide solutions to real world problems in the clinic.


Novel microfluidic and bio-imaging technologies address multiple markets

Assisted Reproductive Technologies (Human & Animal)

More than 70 million couples worldwide cannot conceive naturally and must use assisted reproductive technologies (ART) such as intracytoplasmic sperm injection (ICSI), intrauterine insemination (IUI), or in vitro fertilization (IVF).1,2
In nearly 50% of cases, the problem is attributable to male factors.3 The frequency of male infertility is on the rise and is driving an increasing need for solutions to improve the outcome of ART procedures.

DxNow has designed and developed fertility products to deliver the best outcome for ICSI, IUI and IVF through the use of sperm separation and preparation to aid in selection of the healthiest motile sperm possible.

Interested in learning more about ZyMōt™ Sperm Separation Devices? Visit www.zymotfertility.com.

1 J. Boivin, L.B. Bunting, J.A. Collins, K.G. Nygren, Human Reprod. 2007, 22, 1506.
2  W.Ombelet, L.Cooke, S. Dyer, G.Serour, Human Reprod. Update 2008, 14, 605.
3  R.B. Meacham , G.F. Joyce , M. Wise, A. Kparker, C. Niederberger, J. Urol. 2007, 177 , 2058 – 2066.

Evidence Screening & Differential Extraction For DNA Analysis

More than 200,000 rapes and sexual assaults are reported each year in the United States. Worldwide, in excess of 840,000 cases involve sexual assault4. Every 107 seconds, another American is sexually assaulted. South Africa records the highest rates of rape in the world. According to children’s welfare groups, a woman is raped every 17 seconds in South Africa.

DxNow, in collaboration with The Demirci Bio-Acoustic MEMS in Medicine Labs (BAMM) at Stanford Medicine, has developed microfluidic-based platforms for the capture and sorting of a diverse type of cells and pathogens by utilizing highly specific recognition elements including antibodies and carbohydrates. These platform technologies have the potential of being deployed for the detection, capture and quantitation of multiple cell types from unprocessed samples. We have now applied these state-of-the-art technologies to selectively capture sperm from complex bodily fluids, a step which is crucial in forensic DNA analysis of sexual assault samples. Processing of sexual assault evidence generally requires separation of the victim’s cells (epithelial) from the perpetrator’s cells (sperm) and involves time consuming steps of selective cell lysis, centrifugation and separation into female and male DNA fractions (a process known as differential extraction). DxNow technology will provide a catalyst in helping to reduce DNA forensic backgrounds in cases involving sexual assault evidence. Methods for rapid and efficient processing of sexual assault evidence will accelerate forensic investigation and reduce casework backlogs.

4 http://www.rainn.org/statistics

DxNow leverages its expertise and proprietary technology in biology, microfluidics, imaging, surface chemistry and product design to supply tools for the research community. For example, both the FERTILE™ and FERTILE PLUS™ microfluidic devices may have applications in sperm toxicity for pharmacological R&D, sperm inhibition related to contraception, and genetic and epigenetic influences on sperm function. DxNow’s innovative proprietary lensless holographic shadow imaging in combination with modified surface chemistry has broad application in cell-based and particle-based capture assay detection.

Building on our expertise in cell sorting tools incorporating shadow imaging for detection and characterization of cells, we are developing medical diagnostic devices leveraging these technologies, along with microfluidic integrated biosensors, to capture and quantify cells from unprocessed whole blood or other body fluids. This healthcare platform technology addresses significant underserved clinical needs in the home and primary care settings for innovative, inexpensive, accurate and easy-to-use point-of-care diagnostics products.

Our technology platform is revolutionary. The inexpensive POC monitoring tools that we can deliver to the home or primary setting have not been available to date.

Our products will decrease healthcare costs and have significant clinical and socio-economic benefits.

This platform will deliver accurate, rapid and inexpensive test results, minimizing unnecessary and costly ER visits and hospitalizations. Specifically, our solutions consist of (i) a disposable single use microfluidic cartridge to capture WBCs and neutrophils and (ii) a portable, easy-to-use lens-free shadow imaging system to rapidly quantify captured cell counts. The easy-to-collect measurements and regular monitoring capabilities will provide much needed, timely treatment of patients before their conditions become acute.

Our lead product focuses on significant underserved medical needs in end-stage renal disease; specifically, addressing critical clinical barriers to more widespread use of peritoneal dialysis. Peritoneal dialysis is a preferred treatment modality that can be performed in the home setting, but is often not utilized due to the risk of peritonitis. By leveraging our technologies, we are delivering an inexpensive, disposable diagnostic that can be used in the home setting by patients to easily capture and analyze neutrophils from their dialysate to detect early indicators of peritoneal infection. Early detection of infections at their onset will enable clinicians to start early treatment, providing significant clinical benefits:

  • Detecting infection at the onset and preventing the infection from developing to the chronic phase
  • Monitoring and managing peritoneal dialysis therapy more easily within the home care environment
  • Minimizing repeat infections, which can lead to peritoneal membrane degradation and forcing patients to switch to the more expensive and less convenient hemodialysis treatment.

Beyond monitoring for peritoneal infection, this proposed platform has broad potential application in monitoring patients receiving chemotherapy and transplants, where the need for a rapid and complete blood count is applicable, as well as detecting catheter infections rapidly in many other clinical procedures.

We combine novel, portable bio-imaging systems with microfluidic-based consumables for proprietary life sciences applications that:

  • Deliver improvements in assisted reproductive technology (ART) in humans and animals
  • Facilitate faster identification of individuals for prosecution within the criminal justice system
  • Enable advances in life science research and applied markets
  • Provide faster, more cost-effective diagnostic solutions for chronically ill patients and their caregivers

Our products are based on exclusively-licensed technologies developed in the Demirci BAMM Labs that:

  • Address multiple parallel markets >$31B
  • Enable detection and quantification across a broad spectrum and multiple bio-targets
  • Eliminate sample preparation steps
    • Enable use of unprocessed whole blood, saliva, semen, serum, urine
    • Provide for in vitro cultures on chip / dish / plate

Our Products

Technologies enable detection and quantification of multiple bio-targets



Not an Offer to Purchase or Sell Securities. This overview is for informational purposes and is not an offer to sell or a solicitation of an offer to buy any securities in DxNow, Inc. the “Company” and/or any affiliates. Any offering or solicitation will be made only to qualified prospective investors pursuant to a confidential offering memorandum, and the subscription documents, all of which should be read in their entirety. This business plan contains proprietary information of DxNow, Inc. Neither this business plan nor any of the information contained herein may be reproduced or disclosed to any person without the written consent of DxNow, Inc.

DxNow, Inc. – Introduction and overview


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